Neuropsychological correlates of theory of mind in patients with early Parkinson's disease.
Identifieur interne : 000C95 ( Main/Exploration ); précédent : 000C94; suivant : 000C96Neuropsychological correlates of theory of mind in patients with early Parkinson's disease.
Auteurs : Gabriella Santangelo [Italie] ; Carmine Vitale ; Luigi Trojano ; Domenico Errico ; Marianna Amboni ; Anna Maria Barbarulo ; Dario Grossi ; Paolo BaroneSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2012.
English descriptors
- KwdEn :
- Aged, Cognition Disorders (etiology), Executive Function (physiology), Female, Humans, Male, Middle Aged, Multivariate Analysis, Neuropsychological Tests, Parkinson Disease (complications), Parkinson Disease (psychology), Psychiatric Status Rating Scales, Quality of Life, Statistics as Topic, Theory of Mind (physiology).
- MESH :
- complications : Parkinson Disease.
- etiology : Cognition Disorders.
- physiology : Executive Function, Theory of Mind.
- psychology : Parkinson Disease.
- Aged, Female, Humans, Male, Middle Aged, Multivariate Analysis, Neuropsychological Tests, Psychiatric Status Rating Scales, Quality of Life, Statistics as Topic.
Abstract
The theory of mind is the ability to attribute mental states to oneself and others and to understand that others have beliefs, desires and intentions different from one's own. The aim of the study was to explore the neuropsychological correlates of theory of mind in patients affected by early Parkinson's disease (PD). Thirty-three PD patients and 33 age-, sex-, and education-matched control subjects underwent the Frontal Assessment Battery, as well as tasks assessing "cognitive" and "affective" theory of mind, and memory abilities; questionnaires evaluating behavioral disorders and quality of life were also administrated. Although the 2 groups did not differ on neuropsychological tasks, PD patients' performance on tasks assessing cognitive and affective theory of mind was significantly worse than controls. Moreover, PD patients had more behavioral disorders and worse quality of life than controls. After covarying for behavioral and quality of life scores, the differences between patients and controls on theory of mind tasks remained significant. "Cognitive" theory of mind was associated with Frontal Assessment Battery score and 2 domains of quality of life scale, whereas "affective" theory of mind scores correlated only with behavioral scales such as the Frontal Behavioral Inventory and Apathy Evaluation Scale. The results demonstrate that both affective and cognitive aspects of theory of mind are simultaneously impaired in early PD and suggest that deficits in the 2 subcomponents of theory of mind may be linked to dysfunction of different frontosubcortical circuitries in early PD.
DOI: 10.1002/mds.23949
PubMed: 21915910
Affiliations:
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Trojano</name></author><author><name sortKey="Errico, Domenico" sort="Errico, Domenico" uniqKey="Errico D" first="Domenico" last="Errico">Domenico Errico</name></author><author><name sortKey="Amboni, Marianna" sort="Amboni, Marianna" uniqKey="Amboni M" first="Marianna" last="Amboni">Marianna Amboni</name></author><author><name sortKey="Barbarulo, Anna Maria" sort="Barbarulo, Anna Maria" uniqKey="Barbarulo A" first="Anna Maria" last="Barbarulo">Anna Maria Barbarulo</name></author><author><name sortKey="Grossi, Dario" sort="Grossi, Dario" uniqKey="Grossi D" first="Dario" last="Grossi">Dario Grossi</name></author><author><name sortKey="Barone, Paolo" sort="Barone, Paolo" uniqKey="Barone P" first="Paolo" last="Barone">Paolo Barone</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2012">2012</date><idno type="doi">10.1002/mds.23949</idno><idno type="RBID">pubmed:21915910</idno><idno type="pmid">21915910</idno><idno 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xml:lang="fr">Italie</country><wicri:regionArea>Neuropsychology Laboratory, Department of Psychology, Second University of Naples, Caserta</wicri:regionArea><wicri:noRegion>Caserta</wicri:noRegion></affiliation></author><author><name sortKey="Vitale, Carmine" sort="Vitale, Carmine" uniqKey="Vitale C" first="Carmine" last="Vitale">Carmine Vitale</name></author><author><name sortKey="Trojano, Luigi" sort="Trojano, Luigi" uniqKey="Trojano L" first="Luigi" last="Trojano">Luigi Trojano</name></author><author><name sortKey="Errico, Domenico" sort="Errico, Domenico" uniqKey="Errico D" first="Domenico" last="Errico">Domenico Errico</name></author><author><name sortKey="Amboni, Marianna" sort="Amboni, Marianna" uniqKey="Amboni M" first="Marianna" last="Amboni">Marianna Amboni</name></author><author><name sortKey="Barbarulo, Anna Maria" sort="Barbarulo, Anna Maria" uniqKey="Barbarulo A" first="Anna Maria" last="Barbarulo">Anna Maria Barbarulo</name></author><author><name sortKey="Grossi, Dario" sort="Grossi, Dario" uniqKey="Grossi D" first="Dario" last="Grossi">Dario Grossi</name></author><author><name sortKey="Barone, Paolo" sort="Barone, Paolo" uniqKey="Barone P" first="Paolo" last="Barone">Paolo Barone</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Cognition Disorders (etiology)</term><term>Executive Function (physiology)</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Multivariate Analysis</term><term>Neuropsychological Tests</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (psychology)</term><term>Psychiatric Status Rating Scales</term><term>Quality of Life</term><term>Statistics as Topic</term><term>Theory of Mind (physiology)</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Cognition Disorders</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Executive Function</term><term>Theory of Mind</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Multivariate Analysis</term><term>Neuropsychological Tests</term><term>Psychiatric Status Rating Scales</term><term>Quality of Life</term><term>Statistics as Topic</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The theory of mind is the ability to attribute mental states to oneself and others and to understand that others have beliefs, desires and intentions different from one's own. The aim of the study was to explore the neuropsychological correlates of theory of mind in patients affected by early Parkinson's disease (PD). Thirty-three PD patients and 33 age-, sex-, and education-matched control subjects underwent the Frontal Assessment Battery, as well as tasks assessing "cognitive" and "affective" theory of mind, and memory abilities; questionnaires evaluating behavioral disorders and quality of life were also administrated. Although the 2 groups did not differ on neuropsychological tasks, PD patients' performance on tasks assessing cognitive and affective theory of mind was significantly worse than controls. Moreover, PD patients had more behavioral disorders and worse quality of life than controls. After covarying for behavioral and quality of life scores, the differences between patients and controls on theory of mind tasks remained significant. "Cognitive" theory of mind was associated with Frontal Assessment Battery score and 2 domains of quality of life scale, whereas "affective" theory of mind scores correlated only with behavioral scales such as the Frontal Behavioral Inventory and Apathy Evaluation Scale. The results demonstrate that both affective and cognitive aspects of theory of mind are simultaneously impaired in early PD and suggest that deficits in the 2 subcomponents of theory of mind may be linked to dysfunction of different frontosubcortical circuitries in early PD.</div></front></TEI><affiliations><list><country><li>Italie</li></country></list><tree><noCountry><name sortKey="Amboni, Marianna" sort="Amboni, Marianna" uniqKey="Amboni M" first="Marianna" last="Amboni">Marianna Amboni</name><name sortKey="Barbarulo, Anna Maria" sort="Barbarulo, Anna Maria" uniqKey="Barbarulo A" first="Anna Maria" last="Barbarulo">Anna Maria Barbarulo</name><name sortKey="Barone, Paolo" sort="Barone, Paolo" uniqKey="Barone P" first="Paolo" last="Barone">Paolo Barone</name><name sortKey="Errico, Domenico" sort="Errico, Domenico" uniqKey="Errico D" first="Domenico" last="Errico">Domenico Errico</name><name sortKey="Grossi, Dario" sort="Grossi, Dario" uniqKey="Grossi D" first="Dario" last="Grossi">Dario Grossi</name><name sortKey="Trojano, Luigi" sort="Trojano, Luigi" uniqKey="Trojano L" first="Luigi" last="Trojano">Luigi Trojano</name><name sortKey="Vitale, Carmine" sort="Vitale, Carmine" uniqKey="Vitale C" first="Carmine" last="Vitale">Carmine Vitale</name></noCountry><country name="Italie"><noRegion><name sortKey="Santangelo, Gabriella" sort="Santangelo, Gabriella" uniqKey="Santangelo G" first="Gabriella" last="Santangelo">Gabriella Santangelo</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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